First synthesized in Belgium in the late 1950s,
times that of morphine, was introduced into
medical practice in the 1960s as an intravenous
anesthetic under the trade name of Sublimaze.

Today, fentanyls are extensively used for
anesthesia and analgesia. Duragesic is a fentanyl
transdermal patch used in chronic pain
management, and Actiq is a solid formulation of
fentanyl  that dissolves in the mouth.  

Actiq is intended for opiate-tolerant individuals and
is effective in treating breakthrough pain in cancer
patients.

Carfentanil is a fentanyl with an analgesic potency
10,000 times that of morphine and is used in
veterinary practice


Illicit use of pharmaceutical fentanyls first
appeared in the mid-1970s in the medical
community and continues to be a problem in the
United States.

To date, over 12 different analogues of fentanyl
have been produced clandestinely and identified in
the U.S. drug traffic.

The biological effects of the fentanyls are
indistinguishable from those of heroin, with the
exception that the fentanyls may be hundreds of
times more potent.

Fentanyls are most commonly used by intravenous
administration, but like heroin, they may also be
smoked or snorted.
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