Pentazocine

The effort to find an effective analgesic with less
dependence-producing consequences led to the
development of pentazocine (Talwin).

Introduced as an analgesic in 1967, it was frequently
encountered in the illicit trade, usually in combination
with tripelennamine and placed into Schedule IV of the
CSA in 1979. An attempt at reducing the abuse of this
drug was made with the introduction of Talwin Nx.

This product contains a quantity of antagonist
(naloxone) sufficient to counteract the morphine-like
effects of pentazocine if the tablets are dissolved and
injected.

Butorphanol

While butorphanol can be made from thebaine, it is
usually manufactured synthetically.

It was initially available in injectable formulations for
human (Stadol) and veterinary (Torbugesic and
Torbutrol) use. More recently, a nasal spray (Stadol)
became available, and significant diversion and abuse of
this product led to the 1997 control of butorphanol in
Schedule IV of the CSA.

Butorphanol is a clear example of a drug gaining favor as
a drug of abuse only after it became available in a form
that facilitated greater ease of administration (nasal
spray vs. injection).
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